Predictors of radiographic erosion and joint space narrowing progression in patients with early rheumatoid arthritis: a cohort study

Abstract Background Radiographic damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Different mechanisms may underlie their development. The objective of this study was to evaluate predictors these entities separately. Methods Consecutive early RA patients (symptom duration ≤12 months) from a defined area (Malmö, Sweden) recruited during 1995–2005 were investigated. Radiographs hands feet scored by trained reader according the modified Sharp-van der Heijde score. Fat mass lean distribution measured at baseline using dual energy x-ray absorptiometry. Potential erosion JSN progression inclusion 5-year follow-up evaluated. Results Two hundred thirty-three included. 5 years available for 162 patients. median (interquartile) scores 4 (0–8) 8 (1–16), respectively. Rheumatoid factor (RF) robust significant predictor both score progression. In adjusted analyses, anti-CCP antibodies predicted while erythrocyte sedimentation rate predictive outcomes. Smoking high disease activity (DAS28 > 5.1) erosions. Baseline associated with progression, only JSN. Overweight/obesity (BMI ≥ 25 kg/m 2 ) negative ( β = − 0.14, p 0.018, RF, age, score) also when additionally adjusting ever smoking 0.041). Among female patients, effect observed those estimated post-menopausal age (> 51 years), but not younger women. truncal peripheral fat ratio less women, men. Conclusions Overweight had independent status. This seen particular among older women (mainly post-menopausal), younger. Truncal precede BMI influence cartilage might be related hormonal factors.